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KMID : 0377519870120020281
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Chung-Ang Journal of Medicine
1987 Volume.12 No. 2 p.281 ~ p.293
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Role of defunctionalized Jejunal Segment Mucosa on Gastric Acid Output after Roux-en-Y Cholecystojejunostomy
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Abstract
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The role of defunctionalized jejunal mucosa on gastric acid output after Roux-en-Y cholecystojejunostomy was studied in dogs prepared with Heidenhain pouch.
Preoperative and postoperative changes in 24 hour acid outputs, acid outputs at fasting and test meal loading, serum gastrin and secretin concentrations and antral gastrin contents were measured in Roux en-Y cholecystojejunostomy(Group I ) and Roux-en-Y cholecystojejunostomy with mucosal stripping of defunctionalized jejunal segment (Group II ) .
Both 24 hour and fasting acid outputs were increased significantly(p<0. 05) after each procedure, how-ever, the increased ratio of Group I was much higher than that of Group ff . Being compared with preoperative level, postoperative acid outputs after test meal loading increased with highly significant differnce in Group I (p<0.01) and significant difference in Group II (p<0.05). The increased ratio of Group I was much higher than that of Group II . In both groups, the serum gastrin and secretin concentrations and the antral gastrin contents showed no significant change before and after the operation.
These results suggested that the mucosa of the defunctionalized jejunal segment has ´a potential of releasing an acid secretagogue other than gastrin.
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